The expression profile of circANKRD36 and ANKRD36 as diagnostic biomarkers of chronic kidney disease in patients with type 2 diabetes mellitus
نویسندگان
چکیده
Abstract Background The molecular mechanisms for chronic kidney disease (CKD) remain largely unknown and appear to be multifactorial. In the current study, we aimed study circulatory levels of circular ankyrin repeat domain 36 (circANKRD36) ANKRD36 in Egyptian patients with type 2 diabetes mellitus (T2DM) CKD explore their associations progression CKD. This cross-sectional controlled enrolled 60 T2DM 40 controls. Real-time polymerase chain reaction (RT-PCR) real-time quantitative PCR (RT-qPCR) analyses were used detect expression circANKRD36 . Results Our results detected that relative significantly higher compared CircANKRD36 overexpressed macroalbuminuria (0.2316±0.096, 0.0086±0.0035, respectively) microalbuminuria (0.1347±0.032, 0.0037±0.0008, as well normoalbuminuria (0.1261±0.018, 0.0027±0.0004, respectively), p ˂0.001*. Conclusion increased more specifically diabetic nephropathy (DN) macroalbuminuria.
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ژورنال
عنوان ژورنال: Egyptian Journal of Medical Human Genetics
سال: 2021
ISSN: ['2090-2441', '1110-8630']
DOI: https://doi.org/10.1186/s43042-021-00165-w